What is peptide therapy with Semaglutide?

By Kristie Cyrus DCNP: Lets Age Gracefully!



Peptide therapy and Semaglutide have emerged as groundbreaking advancements in medical science, offering new hope and effective solutions for various health conditions. Let’s delve into the intricacies of peptide therapy, with a special focus on Semaglutide, exploring its mechanism of action, benefits, and diverse clinical uses.

Understanding Peptide Therapy

Peptide therapy, a revolutionary branch of medical science, involves the use of peptides to treat a myriad of health conditions. These short chains of amino acids play crucial roles in the body, influencing physiological processes. The applications of peptide therapy are diverse, ranging from hormonal balance to immune system regulation.


Semaglutide: An Overview

Semaglutide, a member of the GLP-1 receptor agonist family, stands out as a significant development in the realm of peptide therapy. Designed to mimic the action of the natural incretin hormone GLP-1, Semaglutide offers a targeted approach to managing diabetes and related conditions. Semaglutide is administered through subcutaneous injection, a method chosen for its effectiveness and patient convenience. Understanding the rationale behind this mode of administration provides insights into the patient experience and the practicalities of Semaglutide therapy. Increased abdominal issues have been reported with oral therapy.

Mechanism of Action

The interaction between Semaglutide and GLP-1 receptors is a pivotal aspect of its mechanism of action. GLP-1 receptors help to regulate insulin sensitivity in the body. In the brain, GLP-1 receptors regulate appetite. Semaglutide enhances insulin sensitivity by its stimulation of the GLP-1 receptor and thus contributes to improved blood glucose control. The mechanism of action that is garnering worldwide attention is Semaglutides action on the GLP-1 receptors in the brain. When the receptors are stimulated in our brain our brain “believes” we are “full”.

In Summary, GLP-1 works by helps people to lose weight 5 ways:

  • It targets the brain centers that regulate appetite, especially after eating, which may help you eat less.
  • It slows down how quickly the stomach empties, which makes you feel fuller for longer.
  • Semaglutide prevents blood sugar “spikes” that contribute to weight gain.
  • GLP-1 receptor agonists have demonstrated the ability to quiet “food noise” in our brains. As a result, we think of food less.

Other Benefits

In the broader context of medical peptides, Semaglutide assumes a role in hormonal therapy. Its ability to influence hormonal pathways makes it a versatile tool not only for diabetes but also for addressing hormonal imbalances and related health concerns. Patients undergoing Semaglutide therapy often experience positive changes in metabolic health. Semaglutide demonstrated a reduction in cardiovascular events and acute cerebral events in patients with a mean age of 65 years and patients with diabetes. GLP-1 agonists may also have beneficial effects on cardiovascular outcomes, by modulating other risk factors, such as endothelial dysfunction, arterial blood pressure, dyslipidemia, and platelet function. (Oxidative Med Cell Longevity 2019: ID 4179676. 2019)

Metabolic Syndrome is the result of at least three of five medical conditions: excess abdominal fat, hypertension, high blood sugar, elevated triglycerides, and low high-density lipoproteins (HDL). Metabolic syndrome is associated with the risk of cardiovascular disease and diabetes. In the U.S., about 25% of the adult population has metabolic syndrome and that percentage increases with age.  GLP-1’s like Semaglutide act directly to mitigate the risk and presence of Metabolic Syndrome and is believed, by this author, to be a drug class that will change longevity and disease for the better. Recovery from Metabolic Syndrome dramatically extends a healthy life.

GLP-1 Analog and Peptide Drug Development

Semaglutide classification as a GLP-1 analog places it within a broader landscape of peptide drug development. Research in this area will innovate and expand treatment options and open new therapeutic avenues. The following are some weight loss drugs in the development pipline.

  • Orforglipron: Oral GLP-1 agonist. Unlike injectable GLP-1 agonist, its made of chemicals not peptides. This allows it to survive your stomach better. This is a once daily pill currently in phase 3 studies. A phase 2 trial found that Orforglipron may help people lose up to 15% of their body weight after about 8 months (36 weeks). Negatively, thus far is reporting higher incidence of nausea, vomiting, and cramping.
  • Danuglipron: Another oral GLP-1 that is similar to Orforglipron. Taken twice daily but thus far is showing mixed results and is not as promising as other GLP-1’s. Study participants have lost up to 13% of their body weight in 32 weeks but more studies will be needed to assess efficacy at a once daily dose. The twice daily study was halted secondary to nausea, vomiting and diarrhea.
  • APH-012: Oral medication that mimics the effects of gastric bypass surgery. The medication works by stimulation of the small intestine in the jejunum. Phase 2 trial ends in 2024. The author was unable to find much more information.
  • ARD-101: Another oral medication, however, this peptide targets bitter taste receptors in your gut and activates appetite suppressing hormones like GLP-1, Glucagon-like peptide-2 (GLP-2) and cholecystokinin. This pill is taken twice daily. Several phase 2 studies will be completed in mid 2024.
  • Cagrisema: Combines two injectable medications (Semaglutide and Cagrilintide). Significant weight loss with manageable side effects. This is a promising medication. Phase 3 Study ends in 2026.
  • Ecnoglutide: Currently being studied in China and there is a phase 1 trial for an oral version.
  • Bimagrumab: This drug represents an approach to weight loss different than its brethren. This drug antagonizes activin and encourages lean muscle growth. Sign me up!! This drug is infused intravenously monthly. Study participants lost 20% of their body fat while gaining 6-7% more lean muscle. Phase two trial completes in 2025.
  • Retatrutide: This is a medication that acts on three pathways and its injected weekly.
    • GLP-1 (Agonist)
    • GIP (glucose-dependent insulinotropic polypeptide)
    • Glucagon

This medication is looking very promising. Currently in stage 3 trials. Study participants have lost up to 24% of their initial body weight in 48 weeks which would represent the most aggressive weight loss among GLP-1’s and related weight loss peptides. Also, a significant finding is a clinically significant decrease in fatty liver deposits.

Injectable Peptide Therapy: A Growing Trend

The future of medicine lies in personalized treatment plans, and peptide therapy exemplifies this trend. Tailoring Semaglutide therapy to individual patient needs marks a significant stride towards more effective and patient-centric healthcare.

In conclusion, the dynamic interplay between peptide therapy and Semaglutide signifies a transformative era in healthcare. The benefits, mechanisms, and clinical uses of Semaglutide underscore its potential to shape the future of medical treatments, offering personalized solutions for diverse health conditions.


Is Semaglutide only used for diabetes treatment?

No, while Semaglutide is primarily used for diabetes management, ongoing research explores its potential applications in other health conditions, including cardiovascular health and weight management.

What sets Semaglutide apart from other diabetes treatments?

Semaglutide stands out due to its efficacy in blood glucose control, positive impact on weight loss, and a favorable side effect profile compared to traditional diabetes treatments.

How is Semaglutide administered?

Semaglutide is administered through subcutaneous injection, a method chosen for its effectiveness and patient convenience.

Can Semaglutide be used in conjunction with other treatments?

In some cases, healthcare providers may recommend combining Semaglutide with other treatments for a comprehensive approach to health management. Consultation with a healthcare professional is essential.

What are the potential future developments in peptide therapy?

Ongoing research in peptide drug development aims to introduce new therapeutic options, potentially expanding the applications of peptide therapy in the future.

2 thoughts on “What is peptide therapy with Semaglutide?”

  1. I do believe all of the points you have said in your article; they certainly very compelling and will undoubtedly be effective. However, the postings are too brief for beginners; could you perhaps extend them a little for the next time? Thank you for the post.

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